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[주간세미나] 2015년 11월 2일
관리자 2015-10-21

<임용택 교수 Lab.>

* 발표자 : Ren Long

* 제목 : Molecular recognition based extracorporeal blood-cleansing device for sepsis therapy

* 내용 : Sepsis, systemic inflammatory response syndrome in response to infections, affects 18 million people worldwide each year, 30-50% of which will die even in state-of-art hospital ICU. The major cause of sepsis is pathogen loading in circulating system, and it also contributes to the severity and mortality in patients. Although it is not efficient, use of broad-spectrum antibiotics is the most common treatment in sepsis therapy. Because of the overuse of antibiotics, the emergence of super bacteria, which have high resistance to antibiotic drugs, becomes a huge threat to human being. Besides, the mortality rate of sepsis increases rapidly with the timing of treatment given to the patients. Extracorporeal blood-cleansing device is promising in dissolving the problems in sepsis treatment. We are designing the materials, which combine porous support with pathogen recognizing protein to make the packing material of blood-cleansing device. Firstly, it will adsorb the pathogens in blood without breaking the cell membrane of bacteria, which will secret LPS, a major contributor in inducing systemic inflammation. Secondly, porous structure can passively adsorb inflammatory cytokines in circulating blood, and this can prevent the impairment of immune system. Finally, compared with antibiotics, the blood-cleansing treatment will not generate any side effect or releasing more LPS. It can be expected that the exclusion of pathogen load and the reduction of cytokine level will improve the survival rate of sepsis patients.

* 발표자 : Muhammad Abrar

* 제목 : Nanogel based targeting of Lymph Nodes for vaccine delivery

* 내용 : Due to the limited efficacy of current vaccines there is great need for designing new vaccines. Lymph nodes are important secondary lymphoid organs which drains the regulatory molecules from tumor microenvironment. Thus lymph nodes are involved in many immune escapes induced by tumors. Dendritic cells and macrophages in these lymph nodes are the main APCs which capture the antigens and after processing it, present it to CD 8+T cells. In the current study we are using small nano particulate cholestrol nanogels (30nm) which can target lymph nodes. According to our observations, 16 hours after injection, these nanogels are targeted to lymph nodes. The main portion of these nanogels is uptaken by macrophages. Some types of macrophages are believed to be involved in cross activation of CD8 + T cells. We also tried to deliver the protein antigens to lymph nodes through these nanogels. Accoding to our observation the antigens were delivered to lymph nodes along with nanogels. By delivery of cancer antigens to lymph nodes through APCs, which can subsequently present these antigens to T cells, the immune systems can be activated against tumors and other diseases. Thus such a strategy can be used to target lymph nodes and deliver antigens. The approach gives useful clues for developing molecular vaccines.

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